Endocrine Abstracts

Calcitonin is a polypeptide hormone synthesized and secreted by the parafollicular cells of the thyroid gland, and has been considered as a good marker for medullary thyroid carcinoma. But several physiologic and pathologic conditions other than medullary thyroid carcinoma have been associated with increased levels of calcitonin. A 39-year old woman was admitted to our hospital for further testing due to high calcitonin level (467 ng/L) measured by immunochemiluminometric assa...

Background: Thyroid function regulates a wide array of metabolic parameters and significantly affects lipoprotein metabolism. Subclinical hypothyroidism (SCH) is the most common thyroid disorder, with a prevalence up to 10% in adult populations. Subclinical hypothyroidism is defined as mild elevation in thyroid stimulating hormones (TSH) in presence of normal free thyroxine (fT4) and free triiodothyronine (fT3). This mild elevation of serum TSH is caused by a minor initial dec...

Introduction: Glucocorticoids (GCs) are the treatment of choice for moderate-to-severe and active Graves’ orbitopathy (GO), but optimal treatment is still undefined as serious side effects are great concern of GC therapy. The aim of the present study was to evaluate tolerability and safety of two different treatment protocols.Methods: Consecutive patients were divided according to the protocol of GC therapy into two groups: combined intravenous and ...

The rarest causes of primary aldosteronism are aldosterone producing carcinoma, ectopic aldosterone secretion and familial aldosteronism. There are also few cases reported of aldosterone and cortisol tumor cosecretion. We present a 38-year-old woman admitted to our hospital because of resistant hypertension, large adrenal tumor and hypokalemia. At age 32 hypertension was diagnosed, but routine laboratory and abdominal ultrasound examination were normal. Few months before admis...

Objectives: The use of levothyroxine (LT4) treatment aiming to improve fertility in euthyroid women with positive thyroid peroxidase antibodies (TPOAb), is not supported by the available evidence, however the extent to which this is applied in clinical practice is unknown. The aim of the study was to document the demographic, work-related characteristics, and therapeutic choices of European physicians in the case of euthyroid infertile women positive for TPOAb.<p class="ab...

Objectives: Some hypothyroid patients are critical of their care, although this appears to vary between countries. The quality of thyroid care delivered, and the perceived patient experience may be influenced by characteristics of specialists such as age, sex, experience, and workplace setting. Here, we aimed to explore geographical differences in thyroid specialist characteristics.Methods: THESIS is a large European questionnaire survey of thyroid speci...

Objectives: The Clinical Activity Score (CAS) is used to measure and classify Graves orbitopathy activity (GO). However, CAS is partly subjective, and the evaluation of its components is binary. As CAS is known to be correlated with TSH receptor antibodies (TRAb), we wanted to evaluate other immunological parameters in the peripheral blood as markers of GO activity.Methods: The study included 32 patients (19 females, 13 males). CAS was evaluated by a sin...

Background: hyroid autoantibodies cross blood-follicle barrier in titer dependent manner and may change oocyte microenvironment with adverse effects on implantation or post-implantation period. Thyroid autoimmunity (TAI) interfers with pregnancy course and newborn anthropometry in pregnancy achieved by assisted reproduction (ART).Objective: To light upon pregnancy course outcomes and newborn anthropometric characteristics regarding TAI in ART programme.<...

Abstract: A 55-year-old woman was admitted to our hospital due to severe hyperthyreosis. She started to feel symptoms of hyper-metabolism four months prior to hospitalization. At that time she was admitted in regional hospital and had gastroenterological examination because of diarrhea. Crohn’s disease was diagnosed and therapy started. At the same time, thyrosupressive therapy started. She had a history of hyperthyreosis thirteen years ago, duodenal hemorrhage ulcer, hyp...

Myxoid adrenocortical adenoma is a rare adenoma originated from adrenal cortex. A 51 years old male patient was admitted to our hospital due to hypertension and hypokalemia. He has a long history of nonregulated hypertension despite multiple antihypertensive medications. Hypokalemia was detected in last two years with potassium levels around 3.0 mmol/l on high supplementation dose up to 10–16 g of KCl/day. He is obese in the past 10 years. His family history was positive...